PPGBIOTEC

Syllabus:

Notions and concepts of economics. The biotechnological market (products, processes, and services): challenges and opportunities. Biotechnological product and process cases.

Bibliography:

- Basic
GAISFORD, J. D. et al. The economics of Biotechnology. Northampton: Edward Elgar, 2001.
PINHO, D. B.; VASCONCELLOS, M. A. S. (Orgs.). Manual de economia. 5ªed. São Paulo: Saraiva, 2010.
ROY, M. J. Biotechnology Operations: principles and practices. Boca Raton: CRC Press,

- Complementary

Syllabus:

Study of the origin of Bioethics, its concepts and its application in Biotechnology. Analysis of biological risks, classification and biological containment measures, disinfection, sterilization, and waste management. Understanding of the National Biosafety System in Biotechnology and the Research Ethics Committees.

Bibliography:

- Basic
BINSFELD, P. C. Fundamentos Técnicos e o Sistema Nacional de Biossegurança em Biotecnologia. Rio de Janeiro: Editora Interciência. 2015. 434 p.
VEATCH, R. M. Bioética. 3. ed. São Paulo: Pearson Education do Brasil, 2014. 256 p.
SILVA, J. V. Bioética: meio ambiente, saúde e pesquisa. São Paulo: Iatria, 2006. 208 p.


- Complementary
HIRATA, M. H.; HIRATA, R. D. C.; MANCINE FILHO, J. Manual de Biossegurança. 2. ed. São Paulo: Editora Manole. 2012. 384 p.
PESSINI, L.; BARCHIFONTAINE, C. P. Problemas atuais de bioética. São Paulo: Centro Universitário São Camilo: Loyola. 2007. 584p.
PESSANHA, L.; WILKINSON, J. Transgênicos, recursos genéticos e segurança alimentar: o que está em jogo nos debates? Campinas: Armazém do Ipe, 2005. 132 p.
TEIXEIRA, P.; VALLE, S. (Orgs). Biossegurança: uma abordagem multidisciplinar. 2. ed. Rio de Janeiro: Fiocruz, 2012.
FUKUYAMA, F.. Nosso futuro pós-humano - Consequências da revolução da biotecnologia. Rio de Janeiro: Rocco, 2003. 268p.

Syllabus:

DNA, RNA, and protein study methods: different extraction and electrophoresis techniques, different PCR protocols, Northern blot, Southern blot, DNA fingerprinting, and proteomics. Methods of studying gene expression. Basic bioinformatics history and analysis. Discussion of articles, presentation of seminars, and practical activities of bioinformatics.

Bibliography:

- Basic
ALBERTS, B. Biologia Molecular da Célula. 5a ed. Porto Alegre, Artes Médicas, 2011.
ZAHA, A. Biologia Molecular Básica. 5a ed. Porto Alegre, Artes Médicas, 2014.
KARP, G. Biologia Celular e Molecular: conceitos e experimentos. 3a ed. Barueri, Manole, 2005.

- Complementary
ALBERTS, B.; BRAY, D. Fundamentos de Biologia Celular: uma introdução à biologia molecular da célula. Porto Alegre, Artes Médicas, 2004.
CELL. Washington: Cell Press, 1974-. http://www.sciencedirect.com/science/journal/00928674
LODISH, H. Biologia celular e molecular. 7a ed. Porto Alegre, Artmed, 2014.
WALTER, P. Fundamentos da biologia celular: uma introdução à biologia molecular da célula. Porto Alegre, Artmed, 2004.
WATSON, J. D. Biologia molecular do gene. 7a ed. Porto Alegre, Artmed, 2015.

Syllabus:

Intellectual property registration processes. Patents and trademarks. National Institute of Industrial Property (INPI) forms. Technology transfer. Patents. Brands. Law No. 9,279, of May 14, 1996. Geographical indications, patents, and trademarks recognized or presented or INPI. INPI - access and resources. Expository classes will be held, such as the use of resources offered by the institution. Didactic material will be made available and legislation relevant. Students will be asked to prepare and discuss trademark and patent legislation, and to present practical work on the area of knowledge.

Bibliography:

- Basic
DEL NERO, P. A. Biotecnologia: análise crítica do marco jurídico regulatório. Porto Alegre: Revistas dos Tribunais, 2008.
IACOMINI, V. Propriedade intelectual e biotecnologia. Curitiba, PR: Juruá, 2009.
PRADO, M. C. A. Contrato internacional de transferência de tecnologia: patente e know-how. Porto Alegre: Livraria do Advogado, 1997.


- Complementary
ABIN. Proteção de conhecimentos sensíveis e sigilos. Brasília: Agência Brasileira de Inteligência, 2007.
ANDREASSI, Tales. Gestão da inovação tecnológica. São Paulo: Thompson Learning, 2007.
BARBOSA, D. B. Uma introdução à propriedade intelectual. 2. ed. rev. atual. Rio de Janeiro: Lumen Juris, 2003.
CORAL, E.; ABREU, A. F. Gestão integrada da inovação: estratégia, organização e desenvolvimento de produtos. São Paulo: Atlas, 2009.
SANTOS, J. A.; CARVALHO, H. G. RBC - Referencial Brasileiro de Competências em Gerenciamento de Projetos (Brazilian National Competence Baseline). Curitiba: ABGP, 2005. Disponível em: www.abgp.org.br.

Syllabus:

Study of functional and health properties and bioactive compounds of foods: evolution of concepts, classification, characterization, legislation, and labeling. Approach of market trends and development of food products with functional properties. Study of the biotechnological processes applied to the development of functional foods. Discussion of clinical and epidemiological trials applied to health. Discussion of articles published in journals. Theoretical-practical project: development of functional food products through biotechnological processes.

Bibliography:

- Basic
JOURNAL OF FUNCTIONAL Foods. Amsterdam: Elsevier, 2009-. Disponível em: http://www.sciencedirect.com/science/journal/17564646
OLIVEIRA, M. N. Tecnologia de produtos lácteos funcionais. São Paulo: Atheneu, 2009.
WILDMAN, R. E. C. Handbook of nutraceuticals and functional foods. Boca Raton: CRC Press, 2007.

- Complementary
COSTA, N. M. B.; ROSA, C. O. B. Alimentos funcionais: componentes bioativos e efeitos fisiológicos. Rio de Janeiro: Rubio, 2011.
ESKIN, N. A. M. Dictionary of nutraceuticals and functional foods. Boca Raton: CRC Press, 2006.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES. Amsterdam: Elsevier, 2000-. http://www.sciencedirect.com/science/journal/14668564
KOBLITZ, M. G. B. Bioquímica de alimentos: teoria e aplicações práticas. Rio de Janeiro: Guanabara Koogan, 2008.
NEESSER, J.; GERMAN, J. B. Bioprocesses and biotechnology for functional foods and nutraceuticals. Nova York: Marcel Dekker, 2004.

Syllabus:

Genetic variation in humans, mutations, and polymorphisms. Analysis of quantitative and qualitative characteristics. Molecular studies of association and genomic scanning. Molecular basis of metabolic diseases, diabetes, cardiovascular diseases, obesity, psychiatric diseases, and cancer. Gene expression and cancer. Environmental modifiers in complex diseases: gene x environment analyzes. Epigenetics. Presentation and discussion of articles published in related journals.

Bibliography:

- Basic
STRACHAN, T. Genética Molecular Humana. 4ª ed. Porto Alegre: Artmed, 2013.
HEDRICK, P. W. Genetics of Populations. 4ª ed. Boston: Jones & Bartlett, 2011.
WATSON, J. D.; MYERS, R. M.; AMY, A. WITKOWSKI, J. A. DNA recombinante: genes e genomas. Porto Alegre: Artmed, 2009.

- Complementary
TURNPENNY, P.; ELLARD, S. E. Genética Médica. 13ª ed. Rio de Janeiro: Elsevier, 2009.
WEINBERG, R. A. A biologia do câncer. Porto Alegre: Artmed, 2008.
SALZANO, F. M. Genômica e evolução: moléculas, organismos, sociedades. São Paulo: Oficina de Textos. 2012.
GENETICS AND MOLECULAR BIOLOGY. Ribeirão Preto: Sociedade Brasileira de Genética, 1998-. Disponível em: http://www.scielo.br/gmb.
NATURE GENETICS. Nature publishing group. Disponível em: http://www.nature.com/ng/index.html.
TRENDS IN MOLECULAR MEDICINE. Amsterdam: Elsevier, 2001-. Disponível em: http://www.sciencedirect.com/science/journal/14714914.

Syllabus:

Study of the concepts of agroecosystems and biological control; agents, methods, and types of biological control; creation, selection, and conservation of biological control agents; insect-plant interaction; biological control applied to conventional systems and to agroecology; use of plant diversity in agroecosystems to maintain natural enemies of herbivores; successful cases of biological control and agroecosystems. Discussion of scientific articles. Field trip and practical laboratory activities.

Bibliography:

- Basic
DEBACH, P.; ROSEN, D. Biological control by natural enemies. 2. ed. Great Britain: Cambridge University Press, 1991.
DREISTADT, S. H. Pests of landscape trees and shrubs: an integrated pest management guide. 2. ed. Richmond: University of California, 2004. 501 p.
ALTIERI, M. A. Agroecology: the science of sustainable agriculture. 2. ed. Boulder: Westview Press, 1995. 433 p.


- Complementary
BUENO, V. H. P. Controle biológico de pragas: produção massal e controle de qualidade. 2. ed. rev. ampl. Lavras: UFLA, 2009. 429 p.
DRIESCHE, R. G. V.; BELLOWS JR., T. S. Biological control. Boston: Kluwer, 1996. 539 p.
FLINT, M. L.; DREISTADT, S. H. Natural enemies handbook: the illustrated guide to biological pest control. Berkeley: University of California Press, c1998.
PARRA, J. R. P.; OLIVEIRA, H. N.; PINTO, A. S. Guia ilustrado de pragas e insetos benéficos dos citros. Piracicaba: Alexandre de Sene Pinto, 2003. 64 p.

Syllabus:

Provide knowledge about probability, descriptive statistics, sample distributions, correlation, regression, chi-square, analysis of variance and post-hoc tests. Practical exercises using biostatistics software.

Bibliography:

- Basic
CALLEGARI-JAQUES, S. M. Bioestatística: princípios e aplicações. Porto Alegre: Artmed, 2008.
VIEIRA, S. Bioestatística: tópicos avançados. 2a ed. Rio de Janeiro: Elsevier, 2003.
ZAR, J. H. Biostatistical analysis. 5a ed. New Jersey: Prentice Hall, 2010.

- Complementary
JEKEL, J. F. Epidemiologia, bioestatística e medicina preventiva. Porto Alegre, ArtMed, 2005.
LANGE, H. Mathematical and statistical methods for genetic analysis. 2nd ed. New York, Springer-Verlag, 2002.
LEE, E. T.; WANG, J. Statistical methods for survival data analysis. 3rd ed. New York, John Wiley and Sons, 2003.
PAGANO, M.; GAUVREAU, K. Princípios de bioestatística. 2a ed. São Paulo, Thomson, 2010.
WEYNE, G. R. S. Bioestatística e validade de trabalhos científicos. 2a ed. Scortecci, 2009.

Syllabus:

Biomembranes, animal and plant cell organelles, principles of cell signaling, genome structure and organization. RNA replication, transcription, processing, and translation. Control of gene expression in prokaryotes and eukaryotes. Discussion of scientific articles in the area.

Bibliography:

- Basic
ALBERTS, B. et al. Biologia molecular da célula. 5. ed. Porto Alegre: Artmed, 2011.
COOPER, G. M. A célula: uma abordagem molecular. 3ed. Porto Alegre: Artmed, 2009.
ZAHA, A.; FERREIRA, H. B.; PASSAGLIA, L. M. P. (Orgs). Biologia molecular básica. 4. ed. Porto Alegre: Artmed, 2012.

- Complementary
CLARK, D. P. Molecular Biology. 2 ed. Rio de Janeiro: Elsevier, 2013.
LEWIN, B. Genes IX. 9. ed. Porto Alegre: Artmed, 2009.
STRACHAN, T. Genética Molecular Humana. 4ª ed. Porto Alegre: Artmed, 2013.
WALTER, P. Fundamentos da biologia celular: uma introdução à biologia molecular da célula. Porto Alegre, Artmed, 2004.
WATSON, J. D. Biologia molecular do gene. 7a ed. Porto Alegre, Artmed, 2015.

Syllabus:

History of the use of biotechnologies in the reproduction of farm animals. Reproductive biotechnologies linked to the male: semen technology and conservation. Manipulation of spermatogenesis. Reproductive biotechnologies linked to the female: Control of the estrous cycle, developmental endocrinology, follicular maturation, and ovulation. Endocrinology of maternal-fetal relationships. In vitro processes: in vitro fertilization, in vitro maturation, embryo transfer. Cryobiology. Evaluation of biotechnological processes in productive and economic indicators. Presentation and discussion of articles published in journals.

Bibliography:

- Basic
GONÇALVES, P. B. D. et al. Biotécnicas aplicadas à reprodução animal. São Paulo: Roca. 2008.
HAFEZ, E. S. E. Reprodução animal. 7. ed. São Paulo: Manole. 2004.
SENGER, P. L. Pathways to pregnancy and Parturition. 2. ed. Pullman: Current Conceptions. 2003.

- Complementary
ALVARENGA, M. A. et al. Amides as cryoprotectants for freezing stallion semen: A review. Animal Reproduction Science, v.89, p.105-113, 2005.
ANIMAL REPRODUCTION. Belo Horizonte: CBRA, 2004-. Disponível em: http://www.cbra.org.br/portal/index.htm
ANIMAL REPRODUCTION SCIENCE. Amsterdam: Elsevier, 1978-. Disponível em: http://www.sciencedirect.com/science/journal/03784320
BARBAS, J. E R. MASCARENHAS. Cryopreservation of domestic animal sperm cells. Cell and Tissue Banking, v.10, p.49-62, 2009.
THERIOGENOLOGY. Amsterdam: Elsevier, 1974-. Disponível em: http://www.sciencedirect.com/science/journal/0093691X

Syllabus:

Economic and environmental importance of natural products. Main classes of secondary metabolites in plants. Isolation and structural determination methods. Synthesis and biosynthesis of natural products. Structural changes in natural products mediated by microorganisms and enzymes. Applications of natural products in biotechnological processes. Presentation of seminars by students and discussion of articles. Practical experiments on biotransformations.

Bibliography:

- Basic
BARREIRO, E. J.; FRAGA, C. A. M. Química medicinal: as bases moleculares da ação dos fármacos. 2. ed. Porto Alegre: Artmed, 2008.
SLATER, A.; SCOTT, N. W.; FOWLER, M R. Plant biotechnology: the genetic manipulation of plants. 2. ed. Hong Kong: Oxford University Press, 2008.
YUNES, R. A.; CECHINEL-FILHO, V. Química de produtos naturais, novos fármacos e a moderna farmacognosia. Itajaí: Editora Univali. 2009.


- Complementary
BRUNETON, J.; VILLAR DEL FRESNO, A.; CARRETERO ACCAME, E. Farmacognosia: fitoquimica, plantas, plantas medicinales. 2. ed. Saragoça: Acribia, 2001.
ROBBERS, J. E.; SPEEDIE, M. K.; TYLER, V. E. Farmacognosia e farmacobiotecnologia. São Paulo: Editorial Premier, 1997.
SAN FELICIANO, A. et al. (Ed.). Manual de determinación estructural de compuestos naturales. Bogotá: CYTED, 2007.
SIMOES, C. M. O.; SCHENCKEL, E. P.; GOSMANN, G.. Farmacognosia: da planta ao medicamento. 4. ed. Porto Alegre: UFRGS, 2002.
YUNES, R. A.; CALIXTO, J. B. Plantas medicinais sob a ótica da química medicinal moderna. Chapecó: Argos, 2001.

Syllabus:

Study of the history and concepts of plant cell and tissue culture; Micropropagation: uses and methods and culture media; growth regulators; understanding of the processes of embryogenesis, organogenesis, and callogenesis and the physiological factors that affect growth and morphogenesis in vitro; organization of a plant tissue culture laboratory, and application of in vitro culture methodologies in practical laboratory activities.

Bibliography:

- Basic
CASTRO, A. C. R. Aspectos práticos da micropropagação de plantas. Ed. Embrapa. 2010. 386 p.
GEORGE, E. F.; HALL, M. A.; DE KLERK, G.. Plant propagation by tissue culture: The Background. Dordrech, The Netherlands: Springer, 2008. V. 1. 501 p.
SOH, W.; BHOJWANI, S. S. (Eds). Morphogenesis in plant tissue cultures. Dordrecht: Kluwer Academic Publishers, 2010.

- Complementary
PUROHIT, S. D. Introduction to Plant Cell, Tissue and Organ Culture. PHI Learning, 2013. 307 p.
TAIZ, L.; ZEIGER, E.. Fisiologia vegetal. Porto Alegre: Artmed, 2004. p.449-484.
TERMIGNONI, R. R. Cultura de Tecidos Vegetais. Porto Alegre: UFRGS. 2005.
THORSE, T. A. In vitro embryogenesis in plants. Springer, 1995. 558 p.
DAVEY, M. R.; ANTHONY, P. Plant cell culture: essential methods. Ed. Wiley-Blackwell, 2010. 256 p.

Syllabus:

Genetic sequencing. Genome, Transcriptome, and Proteome Project. Molecular techniques for the identification of pathogens. Molecular basis and molecular diagnosis of hereditary diseases. Genetic tests and population screening. Discussion of scientific articles. Related practical activities.

Bibliography:

- Basic
ALBERTS, B. et al. Biologia molecular da célula. 5. ed. Porto Alegre: Artmed ,2011.
LODISH, H. et al. Biologia celular e molecular. 5. ed. Porto Alegre: Artmed, 2005.
JORDE, L. B.; CAREY, J. C.; BAMSHAD, M. J. Genética médica. 4.ed. Rio de Janeiro: Elsevier, 2010.

- Complementary
CLARK, D. P. Molecular Biology. 2 ed. Rio de Janeiro: Elsevier, 2013.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. Amsterdam: Elsevier, 1981-. Disponível em: www.sciencedirect.com/science/journal/07328893.
LEWIN, B.. Genes IX. 9. ed. Porto Alegre: Artmed, 2009.
STRACHAN, T.; READ, A. Human molecular genetics. 4. ed. Nova York: Garland Science, 2010.
THE JOURNAL OF MOLECULAR DIAGNOSTICS. Amsterdam: Elsevier, 1999-. Disponível em: www.sciencedirect.com/science/journal/1525157.

Syllabus:

Fundamental concepts of entrepreneurship. Characteristics of entrepreneurs. Notions on the elaboration of a business plan.

Bibliography:

- Basic
CHIAVENATO, I. Empreendedorismo: dando asas ao espírito empreendedor: empreendedorismo e viabilização de novas empresas, um guia compreensivo para iniciar e tocar seu próprio negócio. São Paulo: Saraiva, 2004.
DORNELAS, J. C. A. Empreendedorismo: transformando ideias em negócios. Rio de Janeiro: Campus, 2012.
RAMAL, S. A. et al. Construindo planos de negócios: todos os passos necessários para planejar e desenvolver negócios de sucesso. Rio de Janeiro: Elsevier, 2005.

- Complementary
BIRLEY, S.; LUCINDA, C. R.; MUZYKA, D. F. Dominando os desafios do empreendedor. São Paulo: Makron Books, 2005.
CECCONELLO, A. R.; Ajzental, A. A construção do plano de negócio. São Paulo: Saraiva, 2008.
CASAROTTO, N. Projeto de negócios: estratégias e estudos de viabilidade. São Paulo: Atlas, 2002.
DRUCKER, P. F.; MALFERRARI, C. J. Inovação e espírito empreendedor (entrepreneurship): prática e princípios. São Paulo: Pioneira, 2012.
HIRSCHFELD, H. Engenharia econômica e análise de custos. São Paulo: Atlas, 2012.

Syllabus:

Nuclear, plastidic, and mitochondrial genomes. Interactions between the different genetic compartments. Mechanisms of amplification and variability of the genome. Gene isolation. Genomic and expression libraries. Mutagenesis and genome analysis. Mechanisms of regulation of gene expression in plants. Techniques for evaluating gene expression in plants. Methods of genetic transformation of plants and analysis of transgenic plants. DNA vectors for genetic transformation. Gene constructs, reporter genes, marker genes, promoter and terminator sequences. Examples of transgenic plants for use in agriculture, the pharmaceutical industry, and as tools in the scientific study of plant biology. Possible risks associated with transgenic plants. Presentation and discussion of scientific articles.

Bibliography:

- Basic
BUCHANAN, B. B. Biochemistry and molecular biology of plants. American Society of Plant Physiologists, Rockville, Wiley, 2012.
STEWART JR, C. N. Plant biotechnology and genetics: principles, techniques and applications. New Jersey, Wiley, 2008.
SLATER, A. Plant biotechnology: the genetic manipulation of plants. Hong Kong, Oxford University Press, 2008.


- Complementary
BROWN, T. A. Genomes. 3rd ed. New York, Garland Science, 2007.
CASTRO, A. C. R. Aspectos práticos da micropropagação de plantas. Porto Alegre: Embrapa, 2010. v. 1
TZOTZOS, G. T. Genetically modified plants: assessing safety and managing risk. Amsterdam, Elsevier, 2009.
JOURNAL OF PLANT PHYSIOLOGY. Alemanha: Elsevier GMBH, Urban & Fisher Verlag, 2001-. http://www.sciencedirect.com/science/journal/01761617
TRENDS IN PLANT SCIENCE. Amsterdam: Elsevier, 1996-. http://www.sciencedirect.com/science/journal/13601385

Syllabus:

Human genetic variability. Concepts in pharmacology and drug metabolization. Genomics and the interindividual response to drugs. Effectiveness and adverse effects, development of new drugs. Genes related to pharmacokinetics and pharmacodynamics. Pharmacogenetic tests and their clinical application. Personalized medicine. Ethical aspects. Presentation and discussion of related scientific articles.

Bibliography:

- Basic
ALTMAN, R. B.; FLOCKHART, D.; GOLDSTEIN, D. B. Principles of Pharmacogenetics and Pharmacogenomics. Cambridge: Cambridge Press, 2012.
HALL, I. P.; PIRMOHAMED, M. Pharmacogenetics. Oxford: Taylor e Francis, 2006.
INNOCENTI, F. Pharmacogenomics:methods and protocols. Totowa: Humana Press, 2005.

- Complementary
STRACHAN, T. Genética Molecular Humana. 4ª ed. Porto Alegre: Artmed, 2013.
BRODY, T. M. Farmacologia Humana: da molecular à clínica. 2. ed. Rio de Janeiro: Guanabara, 1997.
BRUNTON, L; LANGELOH, A. As bases farmacológicas da terapêutica de Goodman & Gilman. 12ª ed. Porto Alegre: AMGH, 2012.
GRAHAME-SMITH, D. G. Tratado de farmacologia clínica e farmacoterapia. 3ª ed. Rio de Janeiro: Guanabara, 2004.
PHARMACOLOGY AND THERAPEUTICS. Amsterdam: Elsevier. Disponível em: http://www.sciencedirect.com/science/journal/01637258.
THE PHARMACOGENETICS JOURNAL. Nature publishing group. Disponível em:http://www.nature.com/tpj/index.html.

Syllabus:

Structures and properties of biomolecules. Topics related to the use of molecular tools in the study of biomolecules. Topics in intermediate metabolism. Enzymatic kinetics and their biotechnological applications. Free radicals, antioxidant defenses and redox stress: pharmacological and agri-food applications. Role of free radicals in pathological processes. Bioactive molecules and their interactions in the human organism. Presentation of seminars by students and discussion of articles published in related journals.

Bibliography:

- Basic
LIEBERMAN, M.; MARKS, A. D. Basic medical biochemistry. 3. ed. Baltimore: Lippincott Williams & Wilkins, 2008.
NELSON, D. L.; COX, M. M. Lehninger: principles of biochemistry. 5. ed. New York: W.H. Freeman, 2009.
TRENDS IN FOOD SCIENCE & TECHNOLOGY. Amsterdam: Elsevier, 1990-. Disponível em: http://www.sciencedirect.com/science/journal/09242244


- Complementary
ALBERTS, B. et al. Molecular biology of the cell. 4. ed. New York: Garland Science, 2002.
BAYNES, J; DOMINICZAK, M. H. Bioquímica médica. 2. ed. São Paulo: Manole, 2011.
CHAMPE, P. C.; HARVEY, R. A.; FERRIER, D. R. Biochemistry. 4. ed. Baltimore: Lippincott Williams & Wilkins, 2007.
DEVLIN, T. M. Manual de Bioquímica com Correlações Clínicas. 6. Ed. São Paulo: Blucher, 2000.
FREE RADICAL BIOLOGY AND MEDICINE. Amsterdam: Elsevier, 1987-. Disponível em: http://www.sciencedirect.com/science/journal/08915849
MURRAY, R. K. et al. Harper's illustrated biochemistry. 29. ed. New York: Lange Basic Science, 2012.

Syllabus:

Cell signaling. Cell death: Apoptosis, pyroptosis, oncosis, necrosis. Cell survival: adaptation to chemical and physical insults. Autophagy. Mitochondrial stress. Reticular stress. Neurodegeneration: Parkinson's disease, Alzheimer's disease, Huntington's disease, schizophrenia, bipolar disorder, depression. Cell degeneration in other pathologies: diabetes mellitus, hepatitis, myocardial infarction, cancer. Aging. Tissue integration in pathologies. Consequences of inflammation on cellular fate. Impact of biotechnological products on cell fate. Presentation of seminars and discussion of scientific articles.

Bibliography:

- Basic
CELL. Amsterdam: Elsevier, 1974-. Disponível em http://www.sciencedirect.com/science/journal/00928674.
GREEN, D. R.; REED, J. C. Apoptosis: Physiology and Pathology. 1. ed. Cambridge: Cambridge University Press, 2011.
GREEN, D. R. Means to an End: Apoptosis and Other Cell Death Mechanisms. 1. ed. New York: Cold Spring Harbor Laboratory Press, 2011.

- Complementary
ALBERTS, B.; JOHNSON, A.; LEWIS, J.; ROBERTS, K.; WALTER, P. Biologia Molecular da Célula. 5. ed. Porto Alegre: ArtMed, 2011.
BRADSHAW, R. A.; DENNIS, E. A. Handbook of Cell Signaling. 2. ed. St. Louis: Academic Press, 2009.
CELLULAR SIGNALLING. Amsterdam: Elsevier, 1989-. Disponível em: http://www.sciencedirect.com/science/journal/08986568.
DICKSON, D.; WELLER, R. O. Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders. 2. ed. New Jersey: Wiley-Blackwell, 2011.
NEUROBIOLOGY OF DISEASE. Amsterdam. Elsevier, 1994-. Disponível em: http://www.sciencedirect.com/science/journal/09699961.
PURVES, D.; AUGUSTINE, G. J.; FITZPATRICK, D.; HALL, W. C.; LAMANTIA, A. S.; MCNAMARA, J. O.; WHITE, L. E. Neurociências. 4. ed. Porto Alegre: ArtMed, 2010.
SURH, Y-J. Oxidative stress, inflammation, and health (Oxidative stress and disease). 1. ed. Boca Raton: CRC Press, 2005.

Syllabus:

Study of advanced analytical methods and techniques used in physical-chemical analysis for the identification and quantification of elements and molecules obtained in biotechnological processes. The purpose of this course is to highlight advanced sample preparation methods such as ultrasound, microwave-initiated combustion, solid-phase extraction, cryogenic grinding, improvements in chromatographic and spectroscopic techniques for the detection and quantification of trace elements. Discussion of articles, presentation of seminars by students, and practical classes.

Bibliography:

- Basic
CHRISTIAN, G. D. Analytical chemistry. 5. ed. New York: John Wiley e Sons, 1994.
HARRIS, D. C. Análise química quantitativa. 5. ed. Rio de Janeiro: LTC, 2013.
SKOOG, D. A. Princípios de análise instrumental. 5. ed. Porto Alegre: Bookman, 2008.

- Complementary
COSTA NETO, C. Análise orgânica: métodos e procedimentos para a caracterização de organoquímicos. Rio de Janeiro: UFRJ, 2004.
EWING, G. W. Métodos instrumentais de análise química. São Paulo: Edgard Blücher, 2013.
LANÇAS, F. M. Extração em fase sólida (SPE). São Carlos: Rima, 2004.
SILVERSTEIN, R. M. Identificação espectrométrica de compostos orgânicos. Rio de Janeiro: LTC, 2013.
STUART, B. Biological applications of infrared spectroscopy. Chichester: ACOL, 1997.
TRENDS IN BIOTECHNOLOGY. Amsterdam: Elsevier Science Publishers, 1983-. Disponível http://www.sciencedirect.com/science/journal/01677799

Syllabus:

Agents for biotechnological processes. Isolation of microorganisms of industrial interest. Use of recombinant microorganisms in bioprocess technology. Submerged and solid-state processes. Equipment, operations, and control parameters for industrial biotechnological processes. Methodologies for Experimental Planning and Response Surface Analysis and their applications in bioprocesses. Calculations of yields and productivity. Scaling of equipment and processes. Production and quality control of fermented foods. Production of biomolecules with application in the food industry. Presentation and discussion of articles published in related journals. Theoretical-practical project: development of biotechnological process(s) of interest to the food industry.

Bibliography:

- Basic
AQUARONE, E. et al. Biotecnologia Industrial: Biotecnologia na produção de alimentos. V.4, São Paulo: Editora Edgard Blucher Ltda., 2001.
BASTOS, R. G. Tecnologia das fermentações: Fundamentos de bioprocessos. São Paulo: EdUFSCar, 2010.
JOURNAL OF BIOTECHNOLOGY. Amsterdam: Elsevier Science Publishers, 1983-. Disponível em: http://www.sciencedirect.com/science/journal/01681656

- Complementary
BON, E. P. S.; FERRARA, M. A.; CORVO, M. L. Enzimas em Biotecnologia: produção, aplicações e mercado. Rio de Janeiro: Interciência, 2008.
FOOD AND BIOPRODUCTS PROCESSING. Amsterdam: Elsevier, 1996-. Disponivel em: http://www.sciencedirect.com/science/journal/09603085
LWT - FOOD SCIENCE AND TECHNOLOGY. Amsterdam: Elsevier, 1993-. Disponível em: http://www.sciencedirect.com/science/journal/00236438
ROY, M. J. Biotechnology operations: principles and practices. Boca Raton: CRC, 2011.
SCHMIDELL, W. et al. Biotecnologia Industrial: Engenharia Bioquímica. V.2, São Paulo: Editora Edgard Blucher Ltda., 2001.

Syllabus:

Sample preparation: tissues and fluids. Electrophoresis in non-denaturing condition, SDS-PAGE, 2D SDS-PAGE, differential gel electrophoresis. Mass spectrometry: different types. Post-translational changes: phosphorylation, glycosylation, and sumoylation. Bioinformatics tools applied to proteomics. Cloning and recombinant expression. Presentation of seminars by students, and practical activities in the laboratory.

Bibliography:

- Basic
JOURNAL OF PROTEOMICS. Amsterdam: Elsevier, 2008-. Disponível em: http://www.sciencedirect.com/science/journal/18743919
PROTEIN EXPRESSION AND PURIFICATION. Amsterdam: Elsevier, 1990 Disponível em: http://www.sciencedirect.com/science/journal/10465928
SCOPES, R. K. Protein Purification: Principles and Practice. New York: Springer-Verlag, 2010.

- Complementary
BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - Proteins and Proteomics. Amsterdam: Elsevier, 2002-. Disponível em: http://www.sciencedirect.com/science/journal/15709639
LOVRIC, J. Introducing Proteomics: From concepts to sample separation, mass spectrometry and data analysis. New York: Wiley, 2011.
NELSON, D. L.; COX, M. M. Lehninger: Principles of Biochemistry. New York: W.H. Freeman, 2009.
SIMPSON, J. Proteins and Proteomics: A Laboratory manual. New York: CSH, 2003.
WESTERNMEIER, R.; NAVEN, T.; HÖPKER, H. R. Proteomics in Practice: A Guide to Successful Experimental Design. New York: Wiley, 2008.

Syllabus:

Expression of recombinant proteins. Determination of protein concentration. Types of electrophoresis. Dialysis and other techniques for removing small molecules and detergents. Clarification and extraction. Membrane separation processes. Precipitation techniques. Sample concentration methods. Ion exchange, gel exclusion, reverse phase, hydrophobic, covalent interaction, affinity, affinity in immobilized metal ions chromatography. Chromatography: scale expansion and industrial application. Integration between fermentation and purification processes. Experimental activities in the laboratory, discussion of articles, and presentation of seminars by students.

Bibliography:

- Basic
BAILON, P. et al. Affinity Chromatography. 1 ed. New York: Humana Press, 2000.
PROTEIN EXPRESSION AND PURIFICATION. Amsterdam: Elsevier, 1990-. Disponível em: http://www.sciencedirect.com/science/journal/10465928
SCOPES, R. K. Protein Purification: Principles and Practice. New York: Springer-Verlag, 2010.

- Complementary
BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS AND PROTEOMICS. Amsterdam: Elsevier, 2002-. Disponível http://www.sciencedirect.com/science/journal/15709639
JOURNAL OF PROTEOMICS. Amsterdam: Elsevier, 2008-. Disponível em: http://www.sciencedirect.com/science/journal/18743919
LIMA, U. A. et al. Processos Fermentativos e Enzimáticos: Biotecnologia Industrial, v. 3. São Paulo: Editora Edgard Blucher, 2001.
NELSON, D. L.; COX, M. M. Lehninger: principles of biochemistry. 5. ed. New York: W.H. Freeman, 2008.
PESSOA Jr., A.; KILIKIAN, B. V. Purificação de produtos biotecnológicos. Barueri, SP: Manole Ltda., 2005.

Syllabus:

The student must write a scientific manuscript in English, whose theme and definition of the journal have been previously approved by the advisor. Another Program professor will be responsible for the student's scientific writing credit and should review the graduate student's article in relation to the content, grammar, and final form of the manuscript. The Scientific Writing I credit will be granted to the student through a report issued by the professor responsible for reviewing the article.

Bibliography:

PUBMED. Disponível em: www.ncbi.nlm.nih.gov/pubmed
PORTAL DE PERIÓDICOS DA CAPES. Brasília: MEC/CAPES. Disponível em: www.periodicos.capes.gov.br
SCIENTIFIC ELECTRONIC LIBRARY ONLINE - SciELO. Portal de periódicos. Disponível em: www.scielo.org.
SCIENCE DIRECT. Elsevier B.V. Disponível em: www.sciencedirect.com

Syllabus:

If the manuscript prepared in the course Scientific Writing I or another paper prepared by the student is accepted for publication in a journal of Qualis B2 or higher in Biotechnology, an additional 1 (one) credit will be given to the graduate student. The Scientific Writing II credit will be granted to the student through a document that proves the acceptance of the manuscript.

Bibliography:

PUBMED. Disponível em: www.ncbi.nlm.nih.gov/pubmed
PORTAL DE PERIÓDICOS DA CAPES. Brasília: MEC/CAPES. Disponível em: www.periodicos.capes.gov.br
SCIENTIFIC ELECTRONIC LIBRARY ONLINE - SciELO. Portal de periódicos. Disponível em: www.scielo.org.
SCIENCE DIRECT. Elsevier B.V. Disponível em: www.sciencedirect.com

Syllabus:

Introduction and history of biological control. Ecological bases of biological control. Selection of biological control agents: predators, parasites, and microorganisms. Types of biological control: natural, applied, augmentative and conservative. Development of a biological pest control program and mass mite breeding techniques. Biological control and selectivity in pest management programs. Presentation of seminars by students and discussion of scientific articles. Practical experiments with pest mites using predatory mites, fungi, and bacteria.

Bibliography:

- Basic
ALTERI, M. A.; SILVA, E. N.; NICHOLLS, C. I. O papel da biodiversidade no manejo de pragas. Ribeirão Preto: Holos, 2003.
BIOLOGICAL CONTROL. Amsterdam: Elsevier, 1991-. Disponível em: http://www.sciencedirect.com/science/journal/10499644
PARRA, J. R. P. et al. Controle biológico no Brasil: parasitóides e predadores. São Paulo: Manoele, 2002.

- Complementary
ALVES, S. B. Controle microbiano de insetos. Piracicaba: FEALQ, 1998.
DEBACH, P.; ROSEN, D. Biological control by natural enemies. Cambridge: Cambridge University Press, 1991.
FLINT, M. L.; DREISTADT, S. H. Natural enemies handbook - the illustrated guide to biological pest control. California: University of California Press, 1998.
KNIGHT, J. Natural enemies: people-wildlife conflicts in anthropological perspective. London: Routledge, 2000.
STRINGHETA, P. C.; MUNIZ, J. N. Alimentos orgânicos: produção, tecnologia e certificação. Viçosa: UFV, 2003.
TOWNSEND, C. R.; BEGON, M.; HARPER, J. L. Fundamentos em ecologia. 3. ed. Porto Alegre: Artmed, 2010.
VAN DRIESCHE, R. G.; BELLOWS, T. S. Biological control. Kluwer Academic Publishers, 1996.

Syllabus:

Introduction and history of biological control. Ecological bases of biological control. Selection of biological control agents: predators, parasites, and microorganisms. Types of biological control: natural, applied, augmentative and conservative. Development of a biological pest control program and mass mite breeding techniques. Biological control and selectivity in pest management programs. Presentation of seminars by students and discussion of scientific articles. Practical experiments with pest mites using predatory mites, fungi, and bacteria.

Bibliography:

- Basic
ALBERTS, B. D. et al. Biologia molecular da célula. 5. ed. Porto Alegre: Artes Médicas. 2011.
HAFEZ, E. S. E. Reprodução animal. 7. ed. São Paulo: Manole. 2004.
SENGER, P. L. Pathways to pregnancy and parturition. 2. ed. Pullman: Current Conceptions. 2003.

- Complementary
BURTON, G. J. et al. Anatomy and Genesis of the Placenta. In: JIMMY, D. N. et al. (Ed.). Knobil and neill's physiology of reproduction. 3. ed. St Louis: Academic Press, 2006. p.189-243.
COUSE, J. F. et al. Steroid Receptors in the Ovary and Uterus. In: JIMMY, D. N. et al.(Ed.). Knobil and neill's physiology of reproduction. 3. ed. St Louis: Academic Press, 2006. p.593-678.
EDDY, E. M. The Spermatozoon. In: JIMMY, D. N. et al. (Ed.). Knobil and neill's physiology of reproduction. 3. ed. St Louis: Academic Press, 2006. p.3-54.
FERTILITY AND STERILITY. Amsterdam: Elsevier, 1997-. Disponível em: http://www.sciencedirect.com/science/journal/00150282
JOURNAL DE GYNECOLOGIE OBSTETRIQUE ET BIOLOGIE DE LA REPRODUCTION. Amsterdam: Elsevier, 2004-. Disponível em: http://www.sciencedirect.com/science/journal/03682315
JOURNAL OF PROTEOMICS. Amsteram: Elsevier, 2008-. Disponível em: http://www.sciencedirect.com/science/journal/18743919

Syllabus:

Genetic variability. Nutrigenetics, the influence of genetics on the response to diet. Influence of genetic variation on nutritional needs, interaction with bioactive compounds, and risk of chronic diseases. Nutrigenomics, the influence of nutrients on the functioning of genes. Diet and gene expression. Epigenetic factors, nutrigenomics, and disease prevention. Individualized nutrition. Discussion of articles published in related journals. Presentation of seminars.

Bibliography:

- Basic
KATHLEEN MAHAN, L.; ESCOTT-STUMP, S. Alimentos, nutrição e dietoterapia. 13a ed. Rio de Janeiro: Elsevier, 2012. STRACHAN, T. Genética Molecular Humana. 4ª ed. Porto Alegre: Artmed, 2013. SIMOPOULUS, A.; ORDOVAS, J. Nutrigenetics and nutrigenomics (World review of nutrition and dietetics). Switzerland: Karger, 2004.
- Complementary
GENRO, J. P.; DAL BOSCO, S. M. Nutrigenética e implicações na saúde humana. 1ª ed. São Paulo, Atheneu, 2014.
NELSON, D. L. Princípios de bioquímica de Lehninger. 6ª ed. Porto Alegre: Artmed, 2014.
PALERMO, J. R. Bioquímica da nutrição. São Paulo: Atheneu, 2008.
MOLECULAR GENETICS AND METABOLISM. Amsterdam: Elsevier. Disponível em: http://www.sciencedirect.com/science/journal/10967192.
JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS. Switzerland: Karger. Disponível em: http://www.karger.com/Journal/Issue/266639.

Syllabus:

Teaching practice in an undergraduate course in an area related to the student's master’s thesis, under the supervision of their advisor, providing experience in the teaching area, training graduate students to work in teaching.

Bibliography:

- Basic
GIL, Antonio C. Metodologia do Ensino Superior. 4. ed. São Paulo: Atlas, 2011. 122 p.
JULIATTO, Clemente I. A universidade em busca da excelência: um estudo sobre a qualidade da educação. 2. ed. rev. atual. Goiânia-Curitiba: UCG-Champagnat, 2010.
TARDIF, Maurice. Saberes Docentes e Formação Profissional. 13. ed. Petrópolis, RJ: Vozes, 2012. 328 p.

- Complementary
ALVES, Rubem. Conversas com quem gosta de ensinar. 14. ed. Campinas: Papirus, 2012. 128 p.
DEMO, Pedro. Universidade, Aprendizagem e Avaliação: Horizontes Reconstrutivos. 3. ed. Porto Alegre: Ed. Mediação, 2008. 160 p.
MOREIRA, Marco A.; VEIT, Eliane A. Ensino superior: bases teóricas e metodológicas. São Paulo: EPU, 2010. 228 p.
REVISTA EDUCAÇÃO, SOCIEDADE & CULTURAS. Indexada pela Scientific Eletronic Library OnLine - SCIELO. Portal de periódico. Disponível em: http://www.scielo.org/php/index.php.
RIBEIRO, Luis R. de C. Aprendizagem baseada em problemas (PBL): uma experiência no ensino superior. São Carlos: EdUFSCar, 2010. 151 p.
ZABALZA, Miguel A. O ensino universitário: seu cenário e seus protagonistas. 2. ed. Porto Alegre: Artmed, 2007. 240 p.

Syllabus:

Presentations of the research projects developed by the professors of the Program in order to allow the student body knowledge about the works that are being carried out in the different research areas. Round tables on research papers and topics in the area of biotechnology with the participation of students and faculty members of the Program and invited experts. Training on Capes' Journal Portal and Databases.

Bibliography:

- Basic
PORTAL DE PERIÓDICOS DA CAPES. Brasília: MEC/CAPES. Disponível em: www.periodicos.capes.gov.br
SCIENCE DIRECT. Elsevier B.V. Disponível em: www.sciencedirect.com
SCIENTIFIC ELECTRONIC LIBRARY ONLINE - SciELO. Portal de periódicos. Disponível em: www.scielo.org.

- Complementary
BIOTECNOLOGIA, CIÊNCIA & DESENVOLVIMENTO. Brasília: K13 Publicações, 1997-. Disponível em: http://www.biotecnologia.com.br
CURRENT OPINION IN BIOTECHNOLOGY. Londres, Elsevier, 1990-. http://www.sciencedirect.com/science/journal/09581669
JOURNAL OF BIOTECHNOLOGY. Amsterdam, Elsevier Science Publishers, 1983-. http://www.sciencedirect.com/science/journal/01681656
PUBMED. Disponível em: www.ncbi.nlm.nih.gov/pubmed
TRENDS IN BIOTECHNOLOGY. Amsterdam, Elsevier Science Publishers, 1983-. http://www.sciencedirect.com/science/journal/01677799